Signature Allergy & Immunology

Contact Information

  • Office 314-872-3104
  • After Hours 314-872-3104
  • Fax 314-994-7105


  • Monday, Wednesday, Friday, 8:00 AM - 3:00 PM
  • Every other Tuesday, 8:00 AM - 3:00 PM
  • Thursday, 11:00 AM - 6:00 PM
  • Saturday, 8:00 AM - 11:00 AM
  • Office closed on select holidays (see below)

*Allergy injections will only be given by appointments only as to prevent overcrowding of our shot waiting room.


Main Location

Signature Allergy & Immunology
425 North New Ballas
Suite 203
St. Louis, MO 63141
Get directions

Other Locations

Signature Allergy & Immunology – Sullivan
965 Mattox Drive
Building B
Sullivan, MO 63080


Allergic Rhinitis (Hay Fever), Non-Allergic Rhinitis, Asthma, Adult Onset Asthma, Exercise Induced Asthma, Food Allergies, Hives, Acute and Chronic Sinusitis, Insect Allergies, Eczema, Contact Dermatitis, Itchy Skin, Drug Allergies, Immunology Issues, Recurrent Infection, Primary Immune Deficiencies, Skin Tests, Patch Testing, Oral Challenge and Desensitization


Our new office location: 425 North New Ballas, Suite 203, St Louis, MO 63141

Existing Patients: Please use the patient portal to request appointments and communicate with the office. Do not use the “Appointment Request” form on this website to communicate with Dr. Subramanian.

To reduce risk, no children under 16 are allowed at the office unless they have a scheduled appointment. 

Signature Allergy & Immunology is committed to the diagnosis, treatment, and management of asthma and allergy-related conditions. Our board-certified allergist and immunologist treats conditions related to any allergic condition listed above. Patients will be evaluated and tested depending on their medical history. We offer flexible hours and a family-friendly environment.

Please refer to our Patient Forms for new patient packets, preparation for testing and our policies, including cancellation policies. Our doctors accept all major insurances. For more information, please visit our Insurance page.

Our office will be closed the following days:

  • Thursday, November 24
  • Friday, November 25
  • Saturday, November 26: Office is open only for allergy shot patients, from 8 AM to 10:30 AM. Appointments are required, no walk-ins accepted.
  • Saturday, December 24
  • Monday, December 26
  • Monday, January 2
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James Temprano, MD, MHA, MSHI, FAAAAI

James Temprano

St. Louis, MO

  • Allergy and Immunology

Hamsa N. Subramanian, MD

Hamsa N. Subramanian

St. Louis, MO

  • Allergy and Immunology
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Mid-level Providers